Prefrontal Cortex Vistas: A Serotonin Safari
نویسندگان
چکیده
منابع مشابه
The effect of Aerobic Training on Serotonin and Tryptophan Hydroxylase of Prefrontal Cortex in type 2 Diabetic Rats
Background & Aims: Type 2 diabetes (T2D) is a self-management disease and depression is a common problem related to it. One of the causes of depression is serotonin (5-HT) depleted. The enzyme tryptophan hydroxylase (TPH) is known as limiting enzyme in the production of 5-HT in the brain. Aerobic exercise also has proven benefits in treating and reducing the incidence of chronic diseases such a...
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The prefrontal cortex (PFC) plays a central role in processing both normal and pathological affective states and it is among the brain regions most closely associated with stress-related psychopathology in humans. The ventromedial PFC (vmPFC) in particular has been shown to be required for healthy emotional regulation, social function and risk assessment and decision-making. Also this region ex...
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Episodic memory, can be defined as the memory for unique events. The serotonergic system one of the main neuromodulatory systems in the brain appears to play a role in it. The serotonin 2a receptor (5-HT2aR) one of the principal post-synaptic receptors for 5-HT in the brain, is involved in neuropsychiatric and neurological disorders associated with memory deficits. Recognition memory can be def...
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Both serotonin and NMDA signaling in prefrontal cortex (PFC) are implicated in mental disorders, including depression and anxiety. To understand their potential contributions to PFC neuronal excitability, we examined the effect of co-activation of 5-HT and NMDA receptors on action potential firing elicited by depolarizing current injection in PFC pyramidal neurons. In the presence of NMDA, a lo...
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ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2015
ISSN: 1948-7193,1948-7193
DOI: 10.1021/acschemneuro.5b00187